Scientists Edited Beagles’ Genes to Make Them Hypoallergenic

Lisa Selvaggio
by Lisa Selvaggio

If you or someone you know has dog allergies, this news is sure to catch your attention: a pair of beagles were genetically edited to make them hypoallergenic pooches who wouldn’t trigger reactions in people who are allergic to dogs.

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Matt Walker is a geneticist who owns a company called Kindred Companion Sciences. He was able to use CRISPR technology to edit the genes of twin beagles named Bailey and Alfie. This is impressive because beagles aren’t hypoallergenic. And while other dogs would cause Walker to experience allergic reactions like sneezing, he’s able to play with and feed Bailey without any problems.


How the Beagles Were Genetically Edited to Be Hypoallergenic


Scientists edited the genetic code in dog skin cells to turn off the gene that makes one of the proteins, Can f 1, that causes allergies in humans.


Once they had the edited genetic code, they transferred it into eggs that were then put in a beagle surrogate. Two female puppies were born in September 2024, and they were healthy. Plus, the scientists confirmed that their fur and saliva didn’t have the unwanted allergy-causing protein.   


Walker is still allergic to dogs, but Bailey’s body doesn’t produce the protein that causes the reactions, so he’s able to interact with her like someone who doesn’t have dog allergies.


Monitoring and More Research Ahead


It’s important to note that scientists need to keep an eye on Bailey and Alfie to see if they experience any health issues because of the genetic changes that made them hypoallergenic.


Before other hypoallergic dogs can be created with this method, years of monitoring are required. But because the genetic change does naturally occur—albeit rarely—in some dogs, the hope is that it won’t have any negative health effects.  


The experts at Kindred Companion Sciences want to see if the same technique could be successful in other canine breeds. If so, they might be able to breed dogs, including service dogs, who are allergy-free. And if that’s possible, more people like Walker, who otherwise wouldn’t be able to have a dog, will be able to share their homes with one.   


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Lisa Selvaggio
Lisa Selvaggio

Lisa Selvaggio is a freelance writer and editor, and our resident cats-pert, with certifications in pet nutrition and pet first aid. She enjoys producing content that helps people understand animals better so they can give their pets a safe and happy home.

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