Dog Cured of Cancer in Clinical Trial

Lisa Selvaggio
by Lisa Selvaggio

In amazing news, a Golden Retriever named Lola was cured of cancer after receiving a new treatment as part of a clinical trial at UC Davis. Diagnosed in 2023, the 9-year-old dog was originally given less than six months to live, as her aggressive oral melanoma had spread to the lungs. But that prognosis changed after she was referred to the UC Davis William R. Pritchard Veterinary Medical Teaching Hospital.  

Eric Isselee/Shutterstock

Taking a Chance with a Clinical Trial


Allison Roth, Lola’s owner, was given the opportunity to participate in a clinical trial that would study the use of an immunotherapy cancer treatment. Her other option was to provide Lola with palliative radiation to buy her more time. She opted to give the clinical trial a chance.


The study, known as Intravenous Doxorubicin and Inhaled IL-15 Immunotherapy for Treatment of Lung Metastases, was part of a series of clinical trials. And, in the third version that Lola participated in, 10 dogs were included. All of them had been diagnosed with pulmonary metastasis that was over 1 centimeter in size.  


Bad News and Then a Cure


The researchers had already noticed that inhaled IL-15 was helping dogs, with some of them responding well, but many dogs didn’t respond to it. Now, they wanted to see if chemotherapy use could improve the response.


Lola was able to receive the inhaled immunotherapy at home to stimulate her immune system into fighting the cancer. Unfortunately, her body didn’t handle the chemotherapy well. And, after receiving the inhalation treatments, the tumors had worsened, so she was taken out of the trial and given palliative radiation, which helped shrink the oral tumor but didn’t help shrink the tumors in her lungs.


In an unexpected and positive turn of events, after a few months, Lola’s tumors had disappeared. Experts believe that it was because of a delayed response to the clinical trial treatments. Immunotherapies may cause tumors to become bigger prior to shrinking them, and this is known as pseudoprogression.


Researchers will release the findings from the clinical trial, and will continue working on finding ways to help more dogs respond to cancer treatments.


It’s been two years, and Lola is still free of cancer. She will be turning 11 in October.    


Join the PetGuide community. Get the latest pet news and product recommendations by subscribing to our newsletter here.

Lisa Selvaggio
Lisa Selvaggio

Lisa Selvaggio is a freelance writer and editor, and our resident cats-pert, with certifications in pet nutrition and pet first aid. She enjoys producing content that helps people understand animals better so they can give their pets a safe and happy home.

More by Lisa Selvaggio

Next